Model No.: 1666-28-0
4-Bromo-2-hydroxybenzoic acid is also known as 4-bromosalicylic acid, CAS number is 1666-28-0, 4-Bromo-2-hydroxybenzoic acid is conventionally produced by oxidation and acidification. The general procedure is to mix the p-bromotoluene, water and potassium hydroxide, heat till boiling, add potassium permanganate in portions, reflux for 4 hours, and acidify by filtration to obtain a crude product. It is dissolved in ammonia water with dilute ethanol, filtered, neutralized with hydrochloric acid, and washed with water to obtain a finished product. Other synthetic methods mainly include chemical oxidation and indirect electrooxidation. The chemical oxidation process is expensive, has serious environmental pollution, and has relatively low production efficiency. The indirect electro-oxidation method is more complicated.
Now there is a completely new way to synthesize4-Bromo-2-hydroxybenzoic acid CAS 1666-28-0 . The method uses phenol as a raw material, firstly by adding nitric acid and sulfuric acid to form 2-nitrophenol, then adding HCI and zinc powder to synthesize 2-aminophenol, followed by heating in a water bath and adding CH3COCH to obtain 2-acetamidophenol, and then adding FeBr3 and Br2, after the reaction was cooled, CaO2 and ferroferric oxide were added, and after completion of the reaction, the target compound 4-Bromo-2-hydroxybenzoic acid was obtained. The method is not only simple and easy to operate, but also has a mild reaction and no pollution, so that the product yield and purity are significantly improved.
Thera. Category:Organic Intermediate
Cas No.: 1666-28-0
Synonyms:4-Bromo-2-hydroxybenzoic acid 98%;4-Bromosalicyclic acid;4-Bromosalicylic acid, 5-Bromo-2-carboxyphenol;4-Bromosalicylic acid, >=98%;4-BROMOSALICYLIC ACID;4-BROMO-2-HYDROXYBENZOIC ACID;4-Bromo-2-Hydroxybenzoic Acid 2-Hydroxy-4-Bromobenzoic Acid;2-Hydroxy-4-bromobenzoicacid;
Packing:Export worthy packing
Material Safety Data Sheet:Available on request
Taizhou Volsen Chemical Co., Ltd.
Taizhou Volsen Chemical Co., Ltd. is professional in R&D, producing and marketing Pharmaceutical raw materials, pharmaceutical intermediates in China. VOLSEN consists of about 100 experienced employees including 3 PhD and 10 Master, and 35000 sqm facilities including research laboratories, kilo lab, pilot plant and full manufacturing plant,
VOLSEN R&D specialists, quality manager and sales with abundance experience make sure products are reliable and service is professional. The producing person inspect every step of the whole process and check up the quality strictly, in order to insure every batch of raw material achieve the standard of EP,CP, JP,BP etc.Matching to the diversified requirements of companies VOLSEN is steadily marching to reach the peaks.
Volsen owns a professional custom synthesis department, with more than 15 senior scientific research chemical personnels who have a graduate degree or above. We also have an independent scientific management system. Our company integrates years of production experiences and talent reserves that forms a strong R&D production capacity, furthermore we could undertake various chemicals customizations from kg to ton relying on the existing production base and equipment.
Manufacturing Unit is equipped with a facility of progressive reeducation of emissions, effluents and discharge of waste material that are known to have a negative impact on the environment. Besides, Laboratory as well as plant is equipped with latest Machinery, Equipments, Technical personnel & Means of communications.
Due to supply of reliable quality, efficient follow up, scheduled delivery and prompt response to any matter, company wins good comments from customers.
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- Company Name: Taizhou Volsen Chemical Co., Ltd.
- Representative: Mr Chen
- Product/Service: Favipiravir Intermediates , Arbidol Intermediates , Relugolix Intermediates , Vilanterol Intermediates , Remdesivir Intermediates , Umeclidinium Bromide
- Capital (Million US $): 60000000RMB
- Year Established: 2002
- Total Annual Sales Volume (Million US $): Above US$100 Million
- Export Percentage: 91% - 100%
- Total Annual Purchase Volume (Million US $): Below US$1 Million
- No. of Production Lines: 5
- No. of R&D Staff: 91 -100 People
- No. of QC Staff: 11 -20 People
- OEM Services Provided: yes
- Factory Size (Sq.meters): 30,000-50,000 square meters
- Factory Location: Dongying Economic Development Zone , Dongying, Shandong,China
- Contact Person: Ms. Amy Cheng
- Tel: 86-576-88869393
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